Opportunity Information: Apply for PA 18 338
This National Institutes of Health (NIH) funding opportunity, PA-18-338, supports revision applications to existing, active NIH-funded R01 research projects that want to expand their approved aims to include the validation of modern mobile and wireless health tools. The central purpose is to help currently funded projects take advantage of newer technologies such as smartphones, wearable sensors, wireless devices, and related mobile platforms to improve how health-related measurements are captured and how interventions are delivered. The emphasis is on validation, meaning applicants are expected to generate evidence that a tool or system accurately, reliably, and appropriately measures a target construct (for example, symptoms, behaviors, physiology, or environmental exposure) or delivers an intervention as intended, rather than simply building or deploying a new app or device without rigorous testing.
The FOA is specifically for revisions (often called competing revisions) rather than brand-new standalone projects. In practical terms, that means the applicant must already hold an active NIH-supported research project award and is seeking additional support to expand the scope of what has already been peer-reviewed and funded. Projects that already use mobile or wireless tools can propose to strengthen their work by adding validation components enabled by recent advances in hardware, software, data capture methods, connectivity, or analytics. At the same time, the announcement also welcomes revision requests from projects that have not previously used mobile or wireless tools, as long as the research team can demonstrate the scientific and technical expertise to integrate these tools and validate them properly within the context of the parent study.
A key boundary of this announcement is that clinical trials are not allowed. Applicants need to stay within a research design that focuses on tool validation for measurement and/or intervention delivery without moving into a clinical trial framework. In other words, the work can involve evaluating performance, feasibility, usability, reliability, sensitivity to change, adherence, data quality, or comparability to gold-standard measures, but it should not be structured as a clinical trial intended to test the efficacy or effectiveness of a clinical intervention on health outcomes in the way NIH defines clinical trials. The intent is to strengthen the measurement and delivery infrastructure that can support future research, not to run a clinical trial under this mechanism.
The opportunity is categorized as a discretionary NIH grant under the health funding activity area, and it is tied to multiple CFDA program numbers (93.233, 93.242, 93.837, 93.838, 93.839, 93.840), reflecting that multiple NIH institutes and centers may be relevant depending on the disease area or scientific topic of the parent award. While the FOA does not list a specific award ceiling or expected number of awards in the provided data, it is framed as a mechanism to supplement and expand already-funded projects, so budgets and scope are typically expected to be well-justified, targeted, and clearly connected to the parent grant’s objectives and infrastructure.
Eligibility is broad and includes many types of applicant organizations, provided they have an active NIH-supported research project award suitable for revision. Eligible applicants include state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; non-federally recognized tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other organizations meeting NIH requirements. The FOA also explicitly highlights additional eligible groups such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. (foreign) entities. This breadth signals NIH’s interest in promoting innovation and validation work across a wide range of settings and populations, including communities that are often underserved or underrepresented in technology-enabled health research.
From a project fit standpoint, a strong revision application under this FOA would typically show: a clear rationale for why a mobile/wireless approach is now appropriate given advances in the field; a specific plan for validation (for example, benchmarking against established measures, testing reliability across contexts, assessing missingness and bias in real-world data streams, and evaluating acceptability and usability in the target population); and a credible implementation plan that leverages the parent award’s cohort, procedures, or data systems. Because it is a revision, reviewers generally look for tight integration with the parent grant, a persuasive argument that the added work meaningfully extends the science, and evidence that the investigative team can execute the technical and methodological demands of mobile/wireless validation.
The opportunity was created on 2017-11-02, with an original closing date listed as 2019-01-07 in the provided source data. The sponsoring agency is NIH, and the mechanism is an R01 revision pathway focused on validating mobile/wireless health tools for measurement and intervention delivery, while keeping the proposed activities outside of NIH-defined clinical trials.Apply for PA 18 338
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Revision Applications for Validation of Mobile/Wireless Health Tools for Measurement and Intervention (R01) (Clinical Trials Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.242, 93.837, 93.838, 93.839, 93.840.
- This funding opportunity was created on 2017-11-02.
- Applicants must submit their applications by 2019-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Minority HIV/AIDS Research Initiative (MARI) to Build HIV Prevention, Treatment and Research Capacity in Disproportionately Affected Black and Hispanic Communities and Among Historically Underrepresented Researchers Apply for RFA PS 16 00103CONT18 Funding Number: RFA PS 16 00103CONT18 Agency: Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: Case Dependent |
| Innovation Award for Mechanistic Studies to Optimize Mind and Body Interventions in NCCIH High Priority Research Topics (R33 Clinical Trial Required) Apply for PAR 18 115 Funding Number: PAR 18 115 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| Emerging Infectious Sentinel Networks (EISN) Research Apply for RFA CK 16 00103CONT18 Funding Number: RFA CK 16 00103CONT18 Agency: Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: Case Dependent |
| NCCIH Mind and Body Clinical Trial Cooperative Agreement (U01 Clinical Trial Required) Apply for PAR 18 118 Funding Number: PAR 18 118 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Improving Outcomes for Disorders of Human Communication (R21 Clinical Trial Optional) Apply for PA 18 288 Funding Number: PA 18 288 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Population-based HIV Impact Assessments in Resource-Constrained Settings under the President’s Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH14 1409A Funding Number: CDC RFA GH14 1409A Agency: Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Human Studies to Evaluate Promising Medications to Treat Alcohol Use Disorder (R03 Clinical Trial Required) Apply for PA 18 198 Funding Number: PA 18 198 Agency: National Institutes of Health Category: Health Funding Amount: $50,000 |
| Human Studies to Evaluate Promising Medications to Treat Alcohol Use Disorder (R21 Clinical Trial Required) Apply for PA 18 197 Funding Number: PA 18 197 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Systems Biology Approaches using Non-Mammalian Laboratory Animals to Uncover Causes of Neurodegeneration that Might Underlie Alzheimers Disease and Related Dementias (R01 Clinical Trial Not Allowed) Apply for RFA AG 18 021 Funding Number: RFA AG 18 021 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Screening and Brief Alcohol Interventions in Underage and Young Adult Populations (R03 Clinical Trial Optional) Apply for PA 18 200 Funding Number: PA 18 200 Agency: National Institutes of Health Category: Health Funding Amount: $50,000 |
| Alcohol Use Disorders: Behavioral Treatment, Services and Recovery Research (R03 Clinical Trial Optional) Apply for PA 18 201 Funding Number: PA 18 201 Agency: National Institutes of Health Category: Health Funding Amount: $50,000 |
| Alcohol Use Disorders: Behavioral Treatment, Services and Recovery Research (R21 Clinical Trial Optional) Apply for PA 18 202 Funding Number: PA 18 202 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Human Studies to Evaluate Promising Medications to Treat Alcohol Use Disorder (R01 Clinical Trial Required) Apply for PA 18 192 Funding Number: PA 18 192 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Screening and Brief Alcohol Interventions in Underage and Young Adult Populations (R01 Clinical Trial Optional) Apply for PA 18 193 Funding Number: PA 18 193 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Alcohol Use Disorders: Behavioral Treatment, Services and Recovery Research (R01 Clinical Trial Optional) Apply for PA 18 194 Funding Number: PA 18 194 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Screening and Brief Alcohol Interventions in Underage and Young Adult Populations (R21 Clinical Trial Optional) Apply for PA 18 199 Funding Number: PA 18 199 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Mechanisms of Disparities for HIV- Related Co-morbidities in Health Disparity Populations (R01-Clinical Trial Not Allowed) Apply for RFA MD 18 002 Funding Number: RFA MD 18 002 Agency: National Institutes of Health Category: Health Funding Amount: $450,000 |
| NIMH Exploratory/Developmental Research Grant (R21 - Clinical Trial Not Allowed) Apply for PA 18 350 Funding Number: PA 18 350 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
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