Opportunity Information: Apply for RFA DA 27 002
The NIH funding opportunity RFA-DA-27-002 is a limited-competition notice of funding opportunity for cooperative agreement (U01) applications to renew and extend the existing Adolescent Brain Cognitive Development (ABCD) Research Project Sites into the next phase, called the Adolescent Brain Cognitive Development - Extended (ABCD-E) Study. The main purpose is to continue following the original ABCD cohort as they move from adolescence into young adulthood, a developmental window when many key outcomes become more likely to appear or fully unfold, including substance use disorders, mental health conditions, chronic diseases, and other health-related outcomes. This extension is framed as essential for capturing the emergence, timing, and trajectories of these outcomes with the same deeply characterized participants already enrolled in ABCD.
This is not an open competition. Only current award recipients associated with the prior ABCD research project site awards funded under RFA-DA-20-002 are eligible to apply for this renewal. While the general NIH eligible applicant types are broad (for example, various levels of government, higher education institutions, nonprofits, and some for-profit entities), the practical eligibility gate is that the applicant organization must already be part of the currently funded ABCD Research Project Sites under that earlier funding announcement. Applications will still go through standard NIH peer review, and only proposals judged meritorious will be considered for funding, even within this limited pool.
The award mechanism is a U01 cooperative agreement, which signals that the funded work will be carried out as a partnership between the investigators and NIH scientific staff. In cooperative agreements, NIH staff are expected to have substantial scientific and programmatic involvement, meaning awardees should anticipate ongoing coordination, shared decision-making, and active participation in consortium-level activities rather than operating as fully independent, stand-alone projects. The NOFO also specifies "Clinical Trial Not Allowed," indicating the proposed activities must not include a clinical trial as defined by NIH, even though the study involves longitudinal follow-up and extensive human data collection.
ABCD-E is structured as a consortium with three tightly integrated parts: (1) a set of linked Research Project Sites that continue participant follow-up and conduct study visits, (2) a single central Data Analysis, Informatics, and Resource Center that supports data systems, analytics infrastructure, and broad resource sharing, and (3) a single overall Coordinating Center that manages operational alignment across the consortium. This NOFO specifically solicits the Research Project Site component through linked collaborative U01 applications. It is run in parallel with a companion NOFO (RFA-DA-27-003) that seeks applications for the two central centers (the Data Analysis/Informatics/Resource Center and the Coordinating Center). In other words, the full ABCD-E program is being competed in coordinated pieces, and successful implementation depends on close collaboration among sites and the two central hubs.
The opportunity is administered by the National Institutes of Health and falls under health-related assistance listings (CFDA/Assistance Listing numbers 93.273, 93.279, 93.399, and 93.865). The original closing date listed is July 9, 2026. The posted summary does not specify an award ceiling or the expected number of awards, but it emphasizes that funding decisions will follow peer review and that the scope is tied to renewing existing ABCD site capabilities to support extended longitudinal follow-up.
On foreign eligibility, non-U.S. (non-domestic) organizations are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible to apply under this NOFO. However, foreign components are allowed as defined in the NIH Grants Policy Statement, meaning U.S. awardees may include certain defined international elements in the project when appropriately justified and compliant with NIH policy, even though the applicant organization itself must be domestic and already part of the existing ABCD site awards.
Overall, the grant is designed to preserve and build on the unique value of the ABCD cohort by keeping the same research sites engaged, maintaining continuity of study procedures, and extending observation into the period when many clinically and public-health-relevant outcomes become measurable. The emphasis on linked applications, integration with centralized data and coordination infrastructure, and close NIH involvement reflects an intention to run ABCD-E as a single, harmonized national research platform rather than a collection of loosely related site projects.Apply for RFA DA 27 002
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition for the Adolescent Brain Cognitive Development -Extended (ABCD-E) Study-Research Project Sites (U01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273, 93.279, 93.399, 93.865.
- This funding opportunity was created on 2026-06-08.
- Applicants must submit their applications by 2026-07-09. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs): NIH RFA-DA-27-002 (ABCD-E Research Project Sites)
What is RFA-DA-27-002?
RFA-DA-27-002 is a National Institutes of Health (NIH) limited-competition Notice of Funding Opportunity (NOFO) for cooperative agreement (U01) applications to renew and extend existing Adolescent Brain Cognitive Development (ABCD) Research Project Sites into the next phase called the Adolescent Brain Cognitive Development - Extended (ABCD-E) Study.
What is the main goal of the ABCD-E Study in this funding opportunity?
The main purpose is to continue following the original ABCD cohort as participants move from adolescence into young adulthood. This developmental window is highlighted as a period when important outcomes may emerge or become clearer, including substance use disorders, mental health conditions, chronic diseases, and other health-related outcomes. The extension is positioned as essential for capturing when these outcomes appear, their timing, and their trajectories using the same deeply characterized participants already enrolled in ABCD.
Is this an open competition?
No. This is not an open competition. It is a limited-competition opportunity restricted to a specific group of existing NIH award recipients.
Who is eligible to apply?
Only current award recipients associated with the prior ABCD Research Project Site awards funded under RFA-DA-20-002 are eligible to apply for this renewal. While NIH generally recognizes many eligible applicant organization types, this NOFO has a practical eligibility gate: the applicant organization must already be part of the currently funded ABCD Research Project Sites under the earlier funding announcement.
Do applications still go through peer review even though eligibility is limited?
Yes. Applications will still go through standard NIH peer review. Even within the limited pool of eligible applicants, only proposals judged meritorious through peer review will be considered for funding.
What is the award mechanism for this opportunity?
The award mechanism is a U01 cooperative agreement. This mechanism indicates that the project is expected to be carried out as a partnership between the funded investigators and NIH scientific staff.
What does a U01 cooperative agreement mean in practice?
In a cooperative agreement, NIH staff are expected to have substantial scientific and programmatic involvement. Awardees should anticipate ongoing coordination with NIH, shared decision-making, and active participation in consortium-level activities. The work is not described as a fully independent, stand-alone project at each site.
Are clinical trials allowed under this NOFO?
No. The NOFO specifies "Clinical Trial Not Allowed." The proposed activities must not include a clinical trial as defined by NIH, even though the study involves longitudinal follow-up and extensive human data collection.
What part of the overall ABCD-E program does RFA-DA-27-002 fund?
This NOFO specifically solicits the Research Project Site component of ABCD-E through linked collaborative U01 applications. These sites are responsible for continuing participant follow-up and conducting study visits.
How is ABCD-E organized?
ABCD-E is structured as a consortium with three integrated parts: (1) linked Research Project Sites that continue participant follow-up and conduct study visits, (2) a single central Data Analysis, Informatics, and Resource Center supporting data systems, analytics infrastructure, and resource sharing, and (3) a single overall Coordinating Center managing operational alignment across the consortium.
Is there a companion funding opportunity related to this one?
Yes. This NOFO is run in parallel with a companion NOFO, RFA-DA-27-003, which seeks applications for the two central hubs: the Data Analysis/Informatics/Resource Center and the Coordinating Center.
What does it mean that applications are "linked" or "collaborative"?
The NOFO describes the Research Project Site applications as linked collaborative U01 applications, reflecting that ABCD-E is intended to operate as a harmonized national research platform. The design depends on coordination among the sites and the two central hubs rather than isolated site-by-site projects.
Which agency administers this opportunity?
The opportunity is administered by the National Institutes of Health (NIH).
What Assistance Listing (CFDA) numbers are associated with this opportunity?
The opportunity falls under health-related assistance listings with the following numbers: 93.273, 93.279, 93.399, and 93.865.
What is the application due date?
The original closing date listed for this opportunity is July 9, 2026.
Is an award ceiling listed?
The posted summary does not specify an award ceiling.
Does the summary state the expected number of awards?
No. The posted summary does not specify the expected number of awards.
What is the focus of the funding scope for the Research Project Sites?
The scope is tied to renewing existing ABCD site capabilities to support extended longitudinal follow-up of the original cohort as they transition into young adulthood, preserving continuity in study procedures and leveraging the uniquely characterized participants already enrolled.
Are non-U.S. (foreign) organizations eligible to apply?
No. Non-U.S. (non-domestic) organizations are not eligible to apply under this NOFO.
Can a non-U.S. component of a U.S. organization apply?
No. Non-U.S. components of U.S. organizations are not eligible to apply under this NOFO.
Are foreign components allowed at all?
Yes. Foreign components are allowed as defined in the NIH Grants Policy Statement. This means a U.S. awardee may include certain defined international elements in the project when appropriately justified and compliant with NIH policy, even though the applicant organization itself must be domestic and already part of the existing ABCD site awards.
Why does the NOFO emphasize continuity with the existing ABCD cohort and sites?
The opportunity is designed to preserve and build on the unique value of the ABCD cohort by keeping the same research sites engaged, maintaining continuity of study procedures, and extending observation into the period when many clinically and public-health-relevant outcomes become measurable.
Does this NOFO describe ABCD-E as separate site projects or a unified program?
It frames ABCD-E as a single, harmonized national research platform. The emphasis on linked applications, integration with centralized data and coordination infrastructure, and close NIH involvement reflects an intention to operate as an integrated consortium rather than a collection of loosely related projects.
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| Maximizing the Scientific Value of Data Generated by the Environmental influences on Child Health Outcomes (ECHO) Program: Dissertation Grant (R36 - Clinical Trial Not Allowed) Apply for RFA OD 27 006 Funding Number: RFA OD 27 006 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Maximizing the Scientific Value of Data Generated by the Environmental Influences on Child Health Outcomes (ECHO) Program: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32) Apply for RFA OD 27 008 Funding Number: RFA OD 27 008 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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| Logistics Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U24 Clinical Trials Not Allowed) Apply for RFA RM 27 015 Funding Number: RFA RM 27 015 Agency: National Institutes of Health Category: Health Funding Amount: $575,000 |
| PRIMED-AI: Data-to-Model Academic-Industrial Partnerships (D2M-AIP) for Precision Medicine with AI: Integrating Imaging with Multimodal Data (UG3/UH3 Clinical Trial Optional) Apply for RFA RM 27 012 Funding Number: RFA RM 27 012 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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