Opportunity Information: Apply for PAR 18 464
The Clinical and Translational Science Award (CTSA) U54 (Clinical Trial Optional) is a National Institutes of Health (NIH) funding opportunity designed to support institutions that can strengthen and accelerate clinical and translational research. The core aim is to build or enhance a coordinated “hub” of services, expertise, and infrastructure that helps move discoveries from the laboratory into clinical testing and, ultimately, into routine health practice. The program is intended to improve the quality and efficiency of translational and clinical research at the local level while also contributing to broader regional and national research capabilities. Alongside research support, the FOA emphasizes innovation in how translational science is conducted, including improvements in research methods, training approaches, and structured career development pathways for researchers working across the translational spectrum.
This opportunity uses a U54 cooperative agreement mechanism, meaning it is not a typical stand-alone grant where the awardee operates fully independently. Instead, a cooperative agreement generally involves substantial NIH programmatic involvement during the life of the award, with NIH staff working collaboratively with funded sites to help ensure the goals of the CTSA program are met. The FOA is labeled “clinical trial optional,” which indicates applicants may propose clinical trials if appropriate, but a clinical trial is not required in order to apply. The activity category is health, and the CFDA (assistance listing) number associated with this program is 93.350, which corresponds to NIH’s clinical and translational science support.
Eligibility is broad and includes many types of U.S.-based organizations that can contribute to translational research capacity. Beyond the standard pool of eligible applicants, the FOA explicitly notes additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Indian/Native American Tribal Governments (other than federally recognized); eligible federal agencies; faith-based or community-based organizations; regional organizations; and U.S. territories or possessions. At the same time, the FOA draws clear boundaries around foreign involvement: non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. However, “foreign components” may be allowed as defined under the NIH Grants Policy Statement, which typically refers to discrete project elements carried out outside the United States under an otherwise eligible applicant organization, subject to NIH rules and justification.
Administratively, the opportunity is identified by Funding Opportunity Number PAR-18-464 and is offered by the NIH. It is categorized as a discretionary funding opportunity and was originally posted with a creation date of December 5, 2017, with an original closing date of September 25, 2018. The source information provided does not specify an award ceiling or the expected number of awards in the excerpt, so applicants would normally consult the full FOA text and NIH budget guidance to understand typical award sizes, allowable costs, and program expectations for CTSA hubs. Overall, this FOA is geared toward institutions capable of building strong translational research environments and providing shared resources, training, and collaborative structures that improve how clinical and translational studies are designed, carried out, and translated into real-world health impact.Apply for PAR 18 464
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Clinical and Translational Science Award U54 (Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.350.
- This funding opportunity was created on 2017-12-05.
- Applicants must submit their applications by 2018-09-25. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 18 464) also looked into and applied for these:
| Funding Opportunity |
|---|
| Pilot Effectiveness Trials for Post-Acute Interventions and Serivces to Optimize Longer-Term Outcomes (R34-Clinical Trials Required) Apply for PAR 18 431 Funding Number: PAR 18 431 Agency: National Institutes of Health Category: Health Funding Amount: $225,000 |
| NINDS Faculty Development Award to Promote Diversity in Neuroscience Research (K01) - Clinical Trial Not Allowed Apply for PAR 18 490 Funding Number: PAR 18 490 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NINDS Faculty Development Award to Promote Diversity in Neuroscience Research (K01) - Clinical Trial Required Apply for PAR 18 486 Funding Number: PAR 18 486 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Prevention and Treatment Research to Address HIV/AIDS Disparities in Women in the US (R01-Accepting applications that either propose or do not propose clinical trial(s)) Apply for RFA MD 18 004 Funding Number: RFA MD 18 004 Agency: National Institutes of Health Category: Health Funding Amount: $350,000 |
| NIBIB Supplements to NCATS CTSA Programs for Translational Research Teams of Quantitative Researchers and Clinician-Scientists (Admin Supp) Apply for PA 18 426 Funding Number: PA 18 426 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| First in Human and Early Stage Clinical Trials of Novel Investigational Drugs or Devices for Psychiatric Disorders (U01-Clinical Trial Required) Apply for PAR 18 427 Funding Number: PAR 18 427 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Effectiveness Trials for Post-Acute Interventions and Services and Services to Optimize Longer-Term Outcomes (R01-Clinical Trials Required) Apply for PAR 18 430 Funding Number: PAR 18 430 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NEI Audacious Goals Initiative: Translation-Enabling Models to Evaluate Survival and Integration of Regenerated Neurons in the Visual System (U24 Clinical Trials Not Allowed) Apply for RFA EY 17 003 Funding Number: RFA EY 17 003 Agency: National Institutes of Health Category: Health Funding Amount: $1,000,000 |
| Detecting and Preventing Suicide Behavior, Ideation and Self-Harm in Youth in Contact with the Juvenile Justice System (R01- Clinical Trial Required) Apply for PAR 18 479 Funding Number: PAR 18 479 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| NIDCR Dental Specialty and PhD Program (DSPP)(K12-Clinical Trials Not Allowed) Apply for RFA DE 18 012 Funding Number: RFA DE 18 012 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIDCD Early Career Research(ECR) Award (R21 - Clinical Trials Optional) Apply for PAR 18 487 Funding Number: PAR 18 487 Agency: National Institutes of Health Category: Health Funding Amount: $100,000 |
| Exosomes: From Biogenesis and Secretion to the Early Pathogenesis of Alzheimer's Disease (R01 - Clinical Trial Not Allowed) Apply for RFA AG 18 027 Funding Number: RFA AG 18 027 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| Deciphering the Molecular Landscape of Lung Aging in Humans (U01 - Clinical Trial Not Allowed) Apply for RFA HL 19 012 Funding Number: RFA HL 19 012 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Sleep disorders and circadian clock disruption in Alzheimers disease and other dementias of aging (R01 Clinical Trial Not Allowed) Apply for PAR 18 497 Funding Number: PAR 18 497 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| From Association to Function in the Alzheimers Disease Post-Genomics Era (R01 - Clinical Trial Not Allowed) Apply for RFA AG 18 026 Funding Number: RFA AG 18 026 Agency: National Institutes of Health Category: Health Funding Amount: $350,000 |
| Interdisciplinary Research to Understand the Complex Biology of Resilience to Alzheimers Disease Risk (R01 - Clinical Trial Not Allowed) Apply for RFA AG 18 029 Funding Number: RFA AG 18 029 Agency: National Institutes of Health Category: Health Funding Amount: $750,000 |
| NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00-Clinical Trial Required) Apply for PAR 18 432 Funding Number: PAR 18 432 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Pragmatic Trials of Managing Multimorbidity in Alzheimers Disease (R01 Clinical Trial Required) Apply for RFA AG 18 028 Funding Number: RFA AG 18 028 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIBIB Exploratory/Developmental Research Grant Program (R21) (Clinical Trial Optional) Apply for PAR 18 433 Funding Number: PAR 18 433 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Human Subjects Mechanistic and Minimal Risk Studies (R21 Clinical Trial Optional) Apply for PA 18 500 Funding Number: PA 18 500 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
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