Advancing Health Equity through Interventions to Prevent and Address Housing Instability (R01 Clinical Trial Optional) | RFA NR 25 001

Opportunity Information: Apply for RFA NR 25 001

The National Institutes of Health (NIH), through the National Institute of Nursing Research (NINR), is offering an R01 funding opportunity titled "Advancing Health Equity through Interventions to Prevent and Address Housing Instability (Clinical Trial Optional)" (Funding Opportunity Number: RFA-NR-25-001). The central aim is to fund research that directly tackles housing instability as a driver of health inequities, with a clear expectation that funded projects will generate actionable evidence on what works to improve both housing-related outcomes and health outcomes. This opportunity is positioned in the broader context of social determinants of health (SDOH), emphasizing that stable, safe, and affordable housing is not just a background condition but a modifiable factor that can be targeted through well-designed interventions.

Applications are expected to develop, test, and/or evaluate a housing-related intervention, and the intervention must be tied to measurable impacts on at least one health outcome and at least one housing outcome. In practice, this means proposals should go beyond documenting associations between housing and health; they should implement and study a strategy intended to prevent housing instability (such as eviction prevention, rent support navigation, or policy-informed service models) or address it once present (for example, interventions that help people regain stable housing, reduce the harms of homelessness, or support sustained tenancy). The "clinical trial optional" designation signals that applicants may propose rigorous experimental or quasi-experimental designs, including clinical trials when appropriate, but they are not required to structure the study as a clinical trial if another design better fits the intervention and setting.

NINR highlights particular interest in SDOH interventions that modify housing opportunities and in interventions that treat housing instability as a social risk by addressing needs at the individual and/or interpersonal level. That framing points to projects that work where instability is experienced and managed day-to-day, such as within families, caregiving relationships, or service delivery interactions, and that improve access to housing resources, strengthen housing supports, or reduce barriers that keep people from obtaining or maintaining stable housing. The health equity emphasis indicates that projects should be designed to reduce disparities and improve outcomes among populations that are disproportionately affected by housing instability and its health consequences, including groups impacted by structural and social inequities.

The opportunity is a discretionary grant in the NIH R01 mechanism and falls under Education and Health funding activity categories, with CFDA numbers 93.313 and 93.361. The listed award ceiling is $500,000, indicating the maximum amount that can be requested under the terms presented in the source information. The original closing date is 2024-12-13, and the record shows a creation date of 2024-09-24.

Eligibility is broad and includes many types of public and private organizations. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); public housing authorities and Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and other entities. The announcement also explicitly calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions.

At the same time, the opportunity clarifies limits related to foreign participation. Non-domestic (non-U.S.) entities are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply. However, foreign components, as defined by the NIH Grants Policy Statement, are allowed, meaning a U.S.-based applicant may include certain well-justified foreign elements within the project as permitted under NIH policy, even though a foreign organization cannot serve as the applicant organization.

Overall, this grant is designed for teams ready to test real-world housing interventions with rigorous evaluation and a clear line of sight to health equity. Competitive applications will typically align the intervention to a defined housing instability problem, specify the population experiencing inequitable risk, describe the delivery setting and partners (often including community or housing-serving organizations), and lay out credible methods for measuring both housing outcomes (such as stability, eviction, homelessness episodes, or housing quality) and health outcomes (which could include physical health, mental health, chronic disease management, stress-related outcomes, health care use, or other relevant measures tied to the intervention theory).

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Advancing Health Equity through Interventions to Prevent and Address Housing Instability (R01 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.313, 93.361.
• This funding opportunity was created on 2024-09-24.
• Applicants must submit their applications by 2024-12-13. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $500,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA NR 25 001

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